Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible expression and the basal promoter element TATA, serving as the binding site for the TATA-binding protein. Strikingly, these promoters possess a modular structure that allows an essentially inactive basal promoter to be strongly activated. The invoked mechanisms include TFB (transcription factor B) recruitment by the ara-box-binding factor to activate gene expression and modulation of TFB recruitment efficiency to yield differential gene expression.
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February 2011
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Conference Article|
January 19 2011
Archaeal promoter architecture and mechanism of gene activation
Nan Peng;
Nan Peng
*State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070 Wuhan, Hubei, China
†Archaea Centre, Department of Biology, University of Copenhagen, Biocenter, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark
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Xiang Ao;
Xiang Ao
*State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070 Wuhan, Hubei, China
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Yun Xiang Liang;
Yun Xiang Liang
*State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070 Wuhan, Hubei, China
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Qunxin She
Qunxin She
1
†Archaea Centre, Department of Biology, University of Copenhagen, Biocenter, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark
1To whom correspondence should be addressed (email qunxin@bio.ku.dk).
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Publisher: Portland Press Ltd
Received:
September 16 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 99–103.
Article history
Received:
September 16 2010
Citation
Nan Peng, Xiang Ao, Yun Xiang Liang, Qunxin She; Archaeal promoter architecture and mechanism of gene activation. Biochem Soc Trans 1 February 2011; 39 (1): 99–103. doi: https://doi.org/10.1042/BST0390099
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