A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute to progression of the tumour. This review discusses the potential role of CLRs (C-type lectin receptors), expressed by antigen-presenting cells of the immune system, in tumour recognition and immune modulation. Studies in recent years have provided significant insight into the immunomodulatory function of CLR during infections, but their role in cancer remains elusive; some strongly bind tumour cells and antigens, indicating participation in malignancy. The potential to use recombinant CLR as diagnostic tools will also be discussed.
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February 2011
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Conference Article|
January 19 2011
Highly glycosylated tumour antigens: interactions with the immune system
Eirikur Saeland;
Eirikur Saeland
1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Post Box 7057, 1007 MB Amsterdam, The Netherlands
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Yvette van Kooyk
Yvette van Kooyk
1
1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Post Box 7057, 1007 MB Amsterdam, The Netherlands
1To whom correspondence should be addressed (email y.vankooyk@vumc.nl).
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Publisher: Portland Press Ltd
Received:
October 11 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 388–392.
Article history
Received:
October 11 2010
Citation
Eirikur Saeland, Yvette van Kooyk; Highly glycosylated tumour antigens: interactions with the immune system. Biochem Soc Trans 1 February 2011; 39 (1): 388–392. doi: https://doi.org/10.1042/BST0390388
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