Glycotypes, particularly those that terminate with sialic acid and fucose are known to play a fundamental role in human development, during implantation, growth and differentiation of fetal tissues. The present review describes changes in the exposition of terminal sialic acid and fucose isoforms in the amniotic fluid glycoconjugates, α1-acid glycoprotein and fibronectin during critical stages of pregnancy, i.e. second and third trimester, perinatal period, delivery and post-date pregnancy. The distinct amniotic glycoforms are suggested to be implicated in regulatory processes to ensure homoeostasis during pregnancy and to protect the fetus. These may have the potential of becoming additional laboratory makers in obstetrics to monitor pregnancy.
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February 2011
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Conference Article|
January 19 2011
Terminal monosaccharide expression on amniotic glycoproteins as biomarkers of fetus maturity
Magdalena Orczyk-Pawiłowicz;
Magdalena Orczyk-Pawiłowicz
1
1Department of Chemistry and Immunochemistry, Wrocław University of Medicine, Bujwida 44a, 50-345 Wrocław, Poland
1To whom correspondence should be addressed (email morczyk@immchem.am.wroc.pl).
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Iwona Kątnik-Prastowska
Iwona Kątnik-Prastowska
1Department of Chemistry and Immunochemistry, Wrocław University of Medicine, Bujwida 44a, 50-345 Wrocław, Poland
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Publisher: Portland Press Ltd
Received:
September 10 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 344–348.
Article history
Received:
September 10 2010
Citation
Magdalena Orczyk-Pawiłowicz, Iwona Kątnik-Prastowska; Terminal monosaccharide expression on amniotic glycoproteins as biomarkers of fetus maturity. Biochem Soc Trans 1 February 2011; 39 (1): 344–348. doi: https://doi.org/10.1042/BST0390344
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