In response to environmental conditions, NO (nitric oxide) induces global changes in the cellular metabolism of Pseudomonas aeruginosa, which are strictly related to pathogenesis. In particular, at low oxygen tensions and in the presence of NO the denitrification alternative respiration is activated by a key regulator: DNR (dissimilative nitrate respiration regulator). DNR belongs to the CRP (cAMP receptor protein)–FNR (fumarate and nitrate reductase regulatory protein) superfamily of bacterial transcription factors. These regulators are involved in many different pathways and distinct activation mechanism seems to be operative in several cases. Recent results indicate that DNR is a haem protein capable of discriminating between NO and CO (carbon monoxide). On the basis of the available structural data, a suggested activation mechanism is discussed.
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February 2011
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Conference Article|
January 19 2011
The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms
Giorgio Giardina;
Giorgio Giardina
1Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “Sapienza”, P. e Aldo Moro, n. 5, 00185, Rome, Italy
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Nicoletta Castiglione;
Nicoletta Castiglione
1Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “Sapienza”, P. e Aldo Moro, n. 5, 00185, Rome, Italy
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Manuela Caruso;
Manuela Caruso
1Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “Sapienza”, P. e Aldo Moro, n. 5, 00185, Rome, Italy
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Francesca Cutruzzolà;
Francesca Cutruzzolà
1Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “Sapienza”, P. e Aldo Moro, n. 5, 00185, Rome, Italy
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Serena Rinaldo
Serena Rinaldo
1
1Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “Sapienza”, P. e Aldo Moro, n. 5, 00185, Rome, Italy
1To whom correspondence should be addressed (email serena.rinaldo@uniroma1.it).
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Publisher: Portland Press Ltd
Received:
September 13 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 294–298.
Article history
Received:
September 13 2010
Citation
Giorgio Giardina, Nicoletta Castiglione, Manuela Caruso, Francesca Cutruzzolà, Serena Rinaldo; The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms. Biochem Soc Trans 1 February 2011; 39 (1): 294–298. doi: https://doi.org/10.1042/BST0390294
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