Architectural proteins play an important role in compacting and organizing the chromosomal DNA in all three kingdoms of life (Eukarya, Bacteria and Archaea). These proteins are generally not conserved at the amino acid sequence level, but the mechanisms by which they modulate the genome do seem to be functionally conserved across kingdoms. On a generic level, architectural proteins can be classified based on their structural effect as DNA benders, DNA bridgers or DNA wrappers. Although chromatin organization in archaea has not been studied extensively, quite a number of architectural proteins have been identified. In the present paper, we summarize the knowledge currently available on these proteins in Crenarchaea. By the type of architectural proteins available, the crenarchaeal nucleoid shows similarities with that of Bacteria. It relies on the action of a large set of small, abundant and generally basic proteins to compact and organize their genome and to modulate its activity.
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February 2011
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Conference Article|
January 19 2011
Nucleoid-associated proteins in Crenarchaea
Rosalie P.C. Driessen;
Rosalie P.C. Driessen
1Leiden Institute of Chemistry, Gorlaeus Laboratories, Laboratory of Molecular Genetics and Cell Observatory, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
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Remus Th. Dame
Remus Th. Dame
1
1Leiden Institute of Chemistry, Gorlaeus Laboratories, Laboratory of Molecular Genetics and Cell Observatory, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
1To whom correspondence should be addressed (email rtdame@chem.leidenuniv.nl).
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Publisher: Portland Press Ltd
Received:
August 16 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 116–121.
Article history
Received:
August 16 2010
Citation
Rosalie P.C. Driessen, Remus Th. Dame; Nucleoid-associated proteins in Crenarchaea. Biochem Soc Trans 1 February 2011; 39 (1): 116–121. doi: https://doi.org/10.1042/BST0390116
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