Methanococcus maripaludis S2 is a methanogenic archaeon with a well-developed genetic system. Its mesophilic nature offers a simple system in which to perform complementation using bacterial and eukaryotic genes. Although information-processing systems in archaea are generally more similar to those in eukaryotes than those in bacteria, the order Methanococcales has a unique complement of DNA replication proteins, with multiple MCM (minichromosome maintenance) proteins and no obvious originbinding protein. A search for homologues of recombination and repair proteins in M. maripaludis has revealed a mixture of bacterial, eukaryotic and some archaeal-specific homologues. Some repair pathways appear to be completely absent, but it is possible that archaeal-specific proteins could carry out these functions. The replication, recombination and repair systems in M. maripaludis are an interesting mixture of eukaryotic and bacterial homologues and could provide a system for uncovering novel interactions between proteins from different domains of life.
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February 2011
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Conference Article|
January 19 2011
Bacterial and eukaryotic systems collide in the three Rs of Methanococcus
Richard P. Parker;
Richard P. Parker
1Department of Biology (Area 5), University of York, York YO10 5DD, U.K.
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Alison D. Walters;
Alison D. Walters
1Department of Biology (Area 5), University of York, York YO10 5DD, U.K.
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James P.J. Chong
James P.J. Chong
1
1Department of Biology (Area 5), University of York, York YO10 5DD, U.K.
1To whom correspondence should be addressed (email james.chong@york.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 25 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 111–115.
Article history
Received:
August 25 2010
Citation
Richard P. Parker, Alison D. Walters, James P.J. Chong; Bacterial and eukaryotic systems collide in the three Rs of Methanococcus. Biochem Soc Trans 1 February 2011; 39 (1): 111–115. doi: https://doi.org/10.1042/BST0390111
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