The control of gene expression in articular chondrocytes is an essential factor in maintaining the homoeostasis of extracellular matrix synthesis and turnover necessary in healthy articular cartilage. Although much is known of how steady-state levels of gene expression and rates of transcription are altered, there has been a poorer understanding of gene control at the post-transcriptional level and its relevance to cartilage health and disease. Now, an emerging picture is developing of the importance of this tier of gene regulation, driven by in vitro studies and mouse genetic models. This level of cellular regulation represents an as yet unexplored area of potential intervention for the treatment of degenerative cartilage disorders such as osteoarthritis.
Skip Nav Destination
Article navigation
December 2010
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 24 2010
Post-transcriptional gene regulation in chondrocytes
Simon R. Tew;
Simon R. Tew
1
1Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, U.K.
1To whom correspondence should be addressed (email tew@liverpool.ac.uk).
Search for other works by this author on:
Peter D. Clegg
Peter D. Clegg
1Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 09 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (6): 1627–1631.
Article history
Received:
June 09 2010
Citation
Simon R. Tew, Peter D. Clegg; Post-transcriptional gene regulation in chondrocytes. Biochem Soc Trans 1 December 2010; 38 (6): 1627–1631. doi: https://doi.org/10.1042/BST0381627
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.