Synapses, points of contact between axons and dendrites, are conduits for the flow of information in the circuitry of the central nervous system. The strength of synaptic transmission reflects the interconnectedness of the axons and dendrites at synapses; synaptic strength in turn is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, memory formation and consolidation. In the present paper, I review some salient features of translational control of synaptic plasticity.
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Conference Article|
November 24 2010
Translational control of synaptic plasticity
Joel D. Richter
Joel D. Richter
1
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.
1email joel.richter@umassmed.edu
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Publisher: Portland Press Ltd
Received:
June 22 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (6): 1527–1530.
Article history
Received:
June 22 2010
Citation
Joel D. Richter; Translational control of synaptic plasticity. Biochem Soc Trans 1 December 2010; 38 (6): 1527–1530. doi: https://doi.org/10.1042/BST0381527
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