Lysosomes form part of our innate immunity and are an important line of defence against microbes, viruses and parasites. Although it is more than 50 years since de Duve discovered lysosomes, it is only in more recent years that we are slowly unravelling the molecular mechanisms involved in the delivery of material to the lysosome. However, successful intracellular pathogens often have a better grip on the mechanisms involved in delivery to the lysosome and can manipulate membrane trafficking pathways to create an intracellular environment that is favourable for replication. By studying pathogen effector proteins that are secreted into the host's cytosol, we can learn about both pathogen-survival mechanisms and further regulatory elements involved in trafficking to the lysosome.
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December 2010
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Conference Article|
November 24 2010
Manipulation of the host by pathogens to survive the lysosome
Paul R. Pryor;
Paul R. Pryor
1
1Department of Biology (Area 12), University of York, York YO10 5DD, U.K.
1To whom correspondence should be addressed (email paul.pryor@york.ac.uk).
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Sally A. Raines
Sally A. Raines
1Department of Biology (Area 12), University of York, York YO10 5DD, U.K.
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Publisher: Portland Press Ltd
Received:
September 23 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (6): 1417–1419.
Article history
Received:
September 23 2010
Citation
Paul R. Pryor, Sally A. Raines; Manipulation of the host by pathogens to survive the lysosome. Biochem Soc Trans 1 December 2010; 38 (6): 1417–1419. doi: https://doi.org/10.1042/BST0381417
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