The ESCRT (endosomal sorting complex required for transport) machinery is a group of multisubunit protein complexes conserved across phyla that are involved in a range of diverse cellular processes. ESCRT proteins regulate the biogenesis of MVBs (multivesicular bodies) and the sorting of ubiquitinated cargos on to ILVs (intraluminal vesicles) within these MVBs. These proteins are also recruited to sites of retroviral particle assembly, where they provide an activity that allows release of these retroviruses. More recently, these proteins have been shown to be recruited to the intracellular bridge linking daughter cells at the end of mitosis, where they act to ensure the separation of these cells through the process of cytokinesis. Although these cellular processes are diverse, they share a requirement for a topologically unique membrane-fission step for their completion. Current models suggest that the ESCRT machinery catalyses this membrane fission.
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November 24 2010
The ESCRT machinery: a cellular apparatus for sorting and scission
Jeremy Carlton
Jeremy Carlton
1
1Department of Infectious Diseases, King's College London, Guy's Hospital, London SE1 9RT, U.K.
1email Jeremy.Carlton@kcl.ac.uk
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Publisher: Portland Press Ltd
Received:
May 19 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (6): 1397–1412.
Article history
Received:
May 19 2010
Citation
Jeremy Carlton; The ESCRT machinery: a cellular apparatus for sorting and scission. Biochem Soc Trans 1 December 2010; 38 (6): 1397–1412. doi: https://doi.org/10.1042/BST0381397
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