The modelling of OXPHOS (oxidative phosphorylation) in order to integrate all kinetic and thermodynamic aspects of chemiosmotic theory has a long history. We briefly review this history and show how new ways of modelling are required to integrate a local model of the individual respiratory complexes into a global model of OXPHOS and, beyond that, into a reliable overall model of central metabolism.

Keywords:
bc1 complex, oxidative phosphorylation (OXPHOS), respiratory complex, stochastic modelling
© The Authors Journal compilation © 2010 Biochemical Society
2010
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