NATs (natural antisense transcripts) are important regulators of eukaryotic gene expression. Interference between the expression of protein-coding sense transcripts and the corresponding NAT is well documented. In the present review, we focus on an additional, higher-order role of NATs that is currently emerging. The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs.
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Conference Article| July 26 2010
What are natural antisense transcripts good for?
Andreas Werner 1
*RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Publisher: Portland Press Ltd
Received: February 19 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
Andreas Werner, Daniel Swan; What are natural antisense transcripts good for?. Biochem Soc Trans 1 August 2010; 38 (4): 1144–1149. doi: https://doi.org/10.1042/BST0381144
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