The nuclear envelope comprises a distinct compartment at the nuclear periphery that provides a platform for communication between the nucleus and cytoplasm. Signal transfer can proceed by multiple means. Primarily, this is by nucleocytoplasmic trafficking facilitated by NPCs (nuclear pore complexes). Recently, it has been indicated that signals can be transmitted from the cytoskeleton to the intranuclear structures via interlinking transmembrane proteins. In animal cells, the nuclear lamina tightly underlies the inner nuclear membrane and thus represents the protein structure located at the furthest boundary of the nucleus. It enables communication between the nucleus and the cytoplasm via its interactions with chromatin-binding proteins, transmembrane and membrane-associated proteins. Of particular interest is the interaction of the nuclear lamina with NPCs. As both structures fulfil essential roles in close proximity at the nuclear periphery, their interactions have a large impact on cellular processes resulting in affects on tissue differentiation and development. The present review concentrates on the structural and functional lamina–NPC relationship in animal cells and its potential implications to plants.
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Conference Article|
May 24 2010
Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants
Jindriska Fiserova;
Jindriska Fiserova
1
1School of Biological and Biomedical Sciences, Sciences Laboratories, Durham University, South Road, Durham DH1 3LE, U.K.
1To whom correspondence should be addressed (email jindriska.fiserova@durham.ac.uk).
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Martin W. Goldberg
Martin W. Goldberg
1School of Biological and Biomedical Sciences, Sciences Laboratories, Durham University, South Road, Durham DH1 3LE, U.K.
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Publisher: Portland Press Ltd
Received:
December 14 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (3): 829–831.
Article history
Received:
December 14 2009
Citation
Jindriska Fiserova, Martin W. Goldberg; Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants. Biochem Soc Trans 1 June 2010; 38 (3): 829–831. doi: https://doi.org/10.1042/BST0380829
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