A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.

Keywords:
cysteine, DHHC protein, membrane topology, palmitoylation, S-acylation, S-acyltransferase
© The Authors Journal compilation © 2010 Biochemical Society
2010
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