Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing.
Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level
Yilei Liu, David J. Elliott; Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level. Biochem Soc Trans 1 February 2010; 38 (1): 237–241. doi: https://doi.org/10.1042/BST0380237
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