The mRNA export adaptors provide an important link between multiple nuclear mRNA processing events and the mRNA export receptor TAP/NXF1/Mex67p. They are recruited to mRNA through transcriptional and post-transcriptional events, integrating this information to licence mRNA for export. Subsequently they hand mRNA over to TAP and switch TAP to a higher-affinity RNA-binding state, ensuring its stable association with mRNA destined for export. Here we discuss the structure and function of adaptors and how they are recruited to mRNA.

Keywords:
ALY, mRNA export, NXF1, RNA-binding and export factor (REF), serine- and arginine-rich protein (SR protein), TAP
© The Authors Journal compilation © 2010 Biochemical Society
2010
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