The mRNA export adaptors provide an important link between multiple nuclear mRNA processing events and the mRNA export receptor TAP/NXF1/Mex67p. They are recruited to mRNA through transcriptional and post-transcriptional events, integrating this information to licence mRNA for export. Subsequently they hand mRNA over to TAP and switch TAP to a higher-affinity RNA-binding state, ensuring its stable association with mRNA destined for export. Here we discuss the structure and function of adaptors and how they are recruited to mRNA.
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Conference Article| January 19 2010
Structure and function of mRNA export adaptors
Matthew J. Walsh;
Guillaume M. Hautbergue;
Stuart A. Wilson
Stuart A. Wilson 1
1Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, U.K.
1To whom correspondence should be addressed (email email@example.com).
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Publisher: Portland Press Ltd
Received: April 27 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
Matthew J. Walsh, Guillaume M. Hautbergue, Stuart A. Wilson; Structure and function of mRNA export adaptors. Biochem Soc Trans 1 February 2010; 38 (1): 232–236. doi: https://doi.org/10.1042/BST0380232
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