Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.
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Conference Article| November 19 2009
Gene expression networks: competing mRNA decay pathways in mammalian cells
Lynne E. Maquat;
Lynne E. Maquat 1
1Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Lynne E. Maquat, Chenguang Gong; Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans 1 December 2009; 37 (6): 1287–1292. doi: https://doi.org/10.1042/BST0371287
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