+TIPs (plus-end tracking proteins) are an increasing group of molecules that localize preferentially to the end of growing microtubules. +TIPs regulate microtubule dynamics and contribute to the organization of the microtubular network within the cell. Thus they participate in a wide range of cellular processes including cell division, motility and morphogenesis. EB1 (end-binding 1) is a highly conserved key member of the +TIP group that has been shown to modulate microtubule dynamics both in vitro and in cells. EB1 is involved in accurate chromosome segregation during mitosis and in the polarization of the microtubule cytoskeleton in migrating cells. Here, we review recent in vitro studies that have started to reveal a regulating activity of EB1, and its yeast orthologue Mal3p, on microtubule structure. In particular, we examine how EB1-mediated changes in the microtubule architecture may explain its effects on microtubule dynamics.
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October 2009
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Conference Article|
September 21 2009
Structural basis of EB1 effects on microtubule dynamics
Frédéric M. Coquelle;
Frédéric M. Coquelle
1
1Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6026, Institut Fédératif de Recherche 140, Génétique Fonctionnelle Agronomie et Santé, Université de Rennes 1, Campus de Beaulieu, 263, Avenue du Général Leclerc, 35042 Rennes, France
1Correspondence may be addressed to either of these authors (email isabelle.arnal@univ-rennes1.fr or frederic.coquelle@univ-rennes1.fr).
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Benjamin Vitre;
Benjamin Vitre
1Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6026, Institut Fédératif de Recherche 140, Génétique Fonctionnelle Agronomie et Santé, Université de Rennes 1, Campus de Beaulieu, 263, Avenue du Général Leclerc, 35042 Rennes, France
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Isabelle Arnal
Isabelle Arnal
1
1Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6026, Institut Fédératif de Recherche 140, Génétique Fonctionnelle Agronomie et Santé, Université de Rennes 1, Campus de Beaulieu, 263, Avenue du Général Leclerc, 35042 Rennes, France
1Correspondence may be addressed to either of these authors (email isabelle.arnal@univ-rennes1.fr or frederic.coquelle@univ-rennes1.fr).
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Publisher: Portland Press Ltd
Received:
March 11 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (5): 997–1001.
Article history
Received:
March 11 2009
Citation
Frédéric M. Coquelle, Benjamin Vitre, Isabelle Arnal; Structural basis of EB1 effects on microtubule dynamics. Biochem Soc Trans 1 October 2009; 37 (5): 997–1001. doi: https://doi.org/10.1042/BST0370997
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