Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized, providing a fresh opportunity to biorient, whereas correct attachments are stabilized. Tension across the centromere may be the signal that distinguishes different attachment states, as spindle microtubules pull bioriented sister kinetochores in the opposite direction. Destabilization of incorrect attachments requires the Ipl1/Aurora B kinase, which phosphorylates kinetochore substrates that directly interact with microtubules. The present review focuses on how Aurora B regulates attachments in response to centromere tension.
Skip Nav Destination
Article navigation
October 2009
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
September 21 2009
Regulation of kinetochore–microtubule attachments by Aurora B kinase
Dan Liu;
Dan Liu
1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
Search for other works by this author on:
Michael A. Lampson
Michael A. Lampson
1
1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
1To whom correspondence should be addressed (email lampson@sas.upenn.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 18 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (5): 976–980.
Article history
Received:
March 18 2009
Citation
Dan Liu, Michael A. Lampson; Regulation of kinetochore–microtubule attachments by Aurora B kinase. Biochem Soc Trans 1 October 2009; 37 (5): 976–980. doi: https://doi.org/10.1042/BST0370976
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.