Many cytoplasmic cargoes are transported along microtubules using dynein or kinesin molecular motors. As the sorting machinery of the cell needs to be tightly controlled, associated factors are employed to either recruit cargoes to motors or to regulate their activities. In the present review, we concentrate on the BicD (Bicaudal-D) protein, which has recently emerged as an essential element for transport of several important cargoes by the minus-end-directed motor cytoplasmic dynein. BicD was proposed to be a linker bridging cargo and dynein, although recent studies suggest that it may also have roles in the regulation of cargo motility. Here we summarize the current knowledge of the role that BicD plays in the transport of diverse cellular constituents. We catalogue the molecular interactions that underpin these functions and also highlight important questions to be addressed in the future.
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October 2009
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Conference Article|
September 21 2009
Bicaudal-D and its role in cargo sorting by microtubule-based motors
Martin Dienstbier;
Martin Dienstbier
1
1Cell Biology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K.
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Xuan Li
2To whom correspondence should be addressed (email xuanli@mrc-lmb.cam.ac.uk).
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Publisher: Portland Press Ltd
Received:
April 27 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (5): 1066–1071.
Article history
Received:
April 27 2009
Citation
Martin Dienstbier, Xuan Li; Bicaudal-D and its role in cargo sorting by microtubule-based motors. Biochem Soc Trans 1 October 2009; 37 (5): 1066–1071. doi: https://doi.org/10.1042/BST0371066
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