Catalase/peroxidases (KatGs) are bifunctional haem b-containing (Class I) peroxidases with overwhelming catalase activity and substantial peroxidase activity with various one-electron donors. These unique oxidoreductases evolved in ancestral bacteria revealing a complex gene-duplicated structure. Besides being found in numerous bacteria of all phyla, katG genes were also detected in genomes of lower eukaryotes, most prominently of sac and club fungi. Phylogenetic analysis demonstrates the occurrence of two distinct groups of fungal KatGs that differ in localization, structural and functional properties. Analysis of lateral gene transfer of bacterial katGs into fungal genomes reveals that the most probable progenitor was a katG from a bacteroidetes predecessor. The putative physiological role(s) of both fungal KatG groups is discussed with respect to known structure–function relationships in bacterial KatGs and is related with the acquisition of (phyto)pathogenicity in fungi.
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August 2009
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Conference Article|
July 22 2009
Two distinct groups of fungal catalase/peroxidases
Marcel Zámocký;
Marcel Zámocký
1
*Metalloprotein Research Group, Division of Biochemistry, Department of Chemistry, BOKU – University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna Austria
†Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská cesta 21, SK-84551 Bratislava, Slovakia
1To whom correspondence should be addressed (email marcel.zamocky@boku.ac.at).
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Paul G. Furtmüller;
Paul G. Furtmüller
*Metalloprotein Research Group, Division of Biochemistry, Department of Chemistry, BOKU – University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna Austria
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Christian Obinger
Christian Obinger
*Metalloprotein Research Group, Division of Biochemistry, Department of Chemistry, BOKU – University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna Austria
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Publisher: Portland Press Ltd
Received:
March 27 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (4): 772–777.
Article history
Received:
March 27 2009
Citation
Marcel Zámocký, Paul G. Furtmüller, Christian Obinger; Two distinct groups of fungal catalase/peroxidases. Biochem Soc Trans 1 August 2009; 37 (4): 772–777. doi: https://doi.org/10.1042/BST0370772
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