The evolution of protein functions and networks: a family-centric approach

The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure–function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein–protein complexes.