Growth factors provide key instructive cues for tissue formation and repair. However, many natural growth factors are limited in their usefulness for tissue engineering and regenerative applications by their poor retention at desired sites of action, short half-lives in vivo, pleiotropic actions and other features. In the present article, we review approaches to rational design of synthetic growth factors based on mechanisms of receptor activation. Such synthetic molecules can function as simplified ligands with potentially tunable specificity and action. Rational and combinatorial protein engineering techniques allow introduction of additional features into these synthetic growth molecules, as well as natural growth factors, which significantly enhance their therapeutic utility.
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August 2009
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Conference Article|
July 22 2009
Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering
Andrew J. Moss;
Andrew J. Moss
1University of Leicester, Department of Cardiovascular Sciences, RKCSB, P.O. Box 65, Leicester LE2 7LX, U.K.
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Shikha Sharma;
Shikha Sharma
1University of Leicester, Department of Cardiovascular Sciences, RKCSB, P.O. Box 65, Leicester LE2 7LX, U.K.
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Nicholas P.J. Brindle
Nicholas P.J. Brindle
1
1University of Leicester, Department of Cardiovascular Sciences, RKCSB, P.O. Box 65, Leicester LE2 7LX, U.K.
1To whom correspondence should be addressed (email npjb1@le.ac.uk).
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Publisher: Portland Press Ltd
Received:
January 06 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (4): 717–721.
Article history
Received:
January 06 2009
Citation
Andrew J. Moss, Shikha Sharma, Nicholas P.J. Brindle; Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering. Biochem Soc Trans 1 August 2009; 37 (4): 717–721. doi: https://doi.org/10.1042/BST0370717
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