Interactions between inorganic materials and biomolecules at the molecular level, although complex, are commonplace. Examples include biominerals, which are, in most cases, facilitated by and in contact with biomolecules; implantable biomaterials; and food and drug handling. The effectiveness of these functional materials is dependent on the interfacial properties, i.e. the extent of molecular level ‘association’ with biomolecules. The present article gives information on biomolecule–inorganic material interactions and illustrates our current understanding using selected examples. The examples include (i) mechanism of biointegration: the role of surface chemistry and protein adsorption, (ii) towards improved aluminium-containing materials, and (iii) understanding the bioinorganic interface: experiment and modelling. A wide range of experimental techniques (microscopic, spectroscopic, particle sizing, thermal methods and solution methods) are used by the research group to study interactions between (bio)molecules and molecular and colloidal species that are coupled with computational simulation studies to gain as much information as possible on the molecular-scale interactions. Our goal is to uncover the mechanisms underpinning any interactions and to identify ‘rules’ or ‘guiding principles’ that could be used to explain and hence predict behaviour for a wide range of (bio)molecule–mineral systems.
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August 2009
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Conference Article|
July 22 2009
From biominerals to biomaterials: the role of biomolecule–mineral interactions
Carole C. Perry;
Carole C. Perry
1
1Biomolecular and Materials Interface Research Group, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, U.K.
1To whom correspondence should be addressed (email carole.perry@ntu.ac.uk).
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Siddharth V. Patwardhan;
Siddharth V. Patwardhan
1Biomolecular and Materials Interface Research Group, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, U.K.
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Olivier Deschaume
Olivier Deschaume
1Biomolecular and Materials Interface Research Group, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, U.K.
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Publisher: Portland Press Ltd
Received:
February 27 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (4): 687–691.
Article history
Received:
February 27 2009
Citation
Carole C. Perry, Siddharth V. Patwardhan, Olivier Deschaume; From biominerals to biomaterials: the role of biomolecule–mineral interactions. Biochem Soc Trans 1 August 2009; 37 (4): 687–691. doi: https://doi.org/10.1042/BST0370687
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