Hel308 is an SF2 (superfamily 2) helicase with clear homologues in metazoans and archaea, but not in fungi or bacteria. Evidence from biochemistry and genetics implicates Hel308 in remodelling compromised replication forks. In the last 4 years, significant advances have been made in understanding the biochemistry of archaeal Hel308, most recently through atomic structures from cren- and eury-archaea. These are good templates for SF2 helicase function more generally, highlighting co-ordinated actions of accessory domains around RecA folds. We review the emerging molecular biology of Hel308, drawing together ideas of how it may contribute to genome stability through the control of recombination, with reference to paradigms developed in bacteria.
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February 2009
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Conference Article|
January 20 2009
Molecular biology of Hel308 helicase in archaea
Isabel L. Woodman;
Isabel L. Woodman
1School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
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Edward L. Bolt
Edward L. Bolt
1
1School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
1To whom correspondence should be addressed (email ed.bolt@nottingham.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 04 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 74–78.
Article history
Received:
August 04 2008
Citation
Isabel L. Woodman, Edward L. Bolt; Molecular biology of Hel308 helicase in archaea. Biochem Soc Trans 1 February 2009; 37 (1): 74–78. doi: https://doi.org/10.1042/BST0370074
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