The ESCRT (endosomal sorting complex required for transport) machinery consists of a number of cytosolic proteins that make up three functional subcomplexes: ESCRT-I, ESCRT-II and ESCRT-III. These proteins function in multivesicular body formation and cell division and are co-opted by enveloped retroviruses to facilitate viral egress. Analysis of these functions may help illuminate conserved mechanisms of ESCRT function.

Keywords:
endosomal sorting complex required for transport (ESCRT), multivesicular body (MVB), retrovirus, tumour susceptibility gene 101 (Tsg101), vacuolar protein sorting 4 (Vps4), virus
© The Authors Journal compilation © 2009 Biochemical Society
2009
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