Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface. After reaching the early endosome, they are ubiquitinated within their cytosolic domain and are consequently sorted away from recycling receptors. They are then incorporated into intraluminal vesicles within the MVB (multivesicular body) en route to the lysosome, where they are degraded. MVB formation requires the stabilization of the vacuolar domain of the early endosome, the segregation of degradative cargo within this domain (with subsequent incorporation of receptors such as EGFR into intraluminal vesicles) and the physical separation and movement of this domain away from the tubular regions of the early endosome. How these different aspects of MVB biogenesis are coupled is unknown, but ESCRTs (endosomal sorting complexes required for transport) have been identified as key molecular players in driving mitogenic receptor sequestration and formation of intraluminal vesicles. The present review summarizes recent findings within the field and from our laboratory regarding the detailed function of ESCRTs and associated proteins in driving the ubiquitin-dependent sorting of EGFR and in maintaining the domain organization of the early endosome.
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February 2009
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Conference Article|
January 20 2009
ESCRT proteins, endosome organization and mitogenic receptor down-regulation
Philip Woodman
Philip Woodman
1
1Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Received:
July 18 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 146–150.
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Received:
July 18 2008
Citation
Philip Woodman; ESCRT proteins, endosome organization and mitogenic receptor down-regulation. Biochem Soc Trans 1 February 2009; 37 (1): 146–150. doi: https://doi.org/10.1042/BST0370146
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