Recombinases of the RecA family are essential for homologous recombination and underpin genome stability, by promoting the repair of double-stranded DNA breaks and the rescue of collapsed DNA replication forks. Until now, our understanding of homologous recombination has relied on studies of bacterial and eukaryotic model organisms. Archaea provide new opportunities to study how recombination operates in a lineage distinct from bacteria and eukaryotes. In the present paper, we focus on RadA, the archaeal RecA family recombinase, and its homologues in archaea and other domains. On the basis of phylogenetic analysis, we propose that a family of archaeal proteins with a single RecA domain, which are currently annotated as KaiC, be renamed aRadC.
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February 2009
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Conference Article|
January 20 2009
RecA family proteins in archaea: RadA and its cousins
Sam Haldenby;
Sam Haldenby
*Institute of Genetics, School of Biology, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
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Malcolm F. White;
Malcolm F. White
†Centre for Biomolecular Sciences, St Andrews University, North Haugh, St Andrews, Fife KY16 9ST, U.K.
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Thorsten Allers
Thorsten Allers
1
*Institute of Genetics, School of Biology, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
1To whom correspondence should be addressed (email thorsten.allers@nottingham.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 04 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 102–107.
Article history
Received:
August 04 2008
Citation
Sam Haldenby, Malcolm F. White, Thorsten Allers; RecA family proteins in archaea: RadA and its cousins. Biochem Soc Trans 1 February 2009; 37 (1): 102–107. doi: https://doi.org/10.1042/BST0370102
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