The ‘new view’ of proteins sees protein reactions as parallel processes occurring along funnelled energy landscapes. These landscapes are generally not smooth, but are superimposed by hills and valleys of different heights and widths leading to roughness on the energy surface. In the present paper, we describe the origins of protein energy landscape roughness, measurements of its scale and its implications.

Keywords:
energy landscape roughness, force spectroscopy, protein energy landscape, protein folding and binding
© The Authors Journal compilation © 2008 Biochemical Society
2008
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