Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array of diseases caused by lamin mutations. Unlike other intermediate filament proteins, they do not self-assemble into 10 nm filaments in vitro and their in vivo organization is uncertain. We have recently re-examined the organization of a simple B-type lamina in Xenopus oocytes [Goldberg, Huttenlauch, Hutchison and Stick (2008) J. Cell Sci. 121, 215–225] and shown that it consists of tightly packed 8–10 nm filaments with regular cross-connections, tightly opposed to the membrane. When lamin A is expressed in oocytes, it forms organized bundles on top of the B lamina. This has led to a new model for lamina organization which is discussed in the present paper.
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Conference Article|
November 19 2008
A new model for nuclear lamina organization
Martin W. Goldberg;
Martin W. Goldberg
1
*School of Biological and Biomedical Sciences, Durham University, Sciences Laboratories, South Road, Durham DH1 3LE, U.K.
1To whom correspondence should be addressed (email m.w.goldberg@durham.ac.uk).
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Jindriska Fiserova;
Jindriska Fiserova
*School of Biological and Biomedical Sciences, Durham University, Sciences Laboratories, South Road, Durham DH1 3LE, U.K.
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Irm Huttenlauch;
Irm Huttenlauch
†Department of Cell Biology, University of Bremen, P.O. Box 330440, D-28334 Bremen, Germany
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Reimer Stick
Reimer Stick
†Department of Cell Biology, University of Bremen, P.O. Box 330440, D-28334 Bremen, Germany
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Publisher: Portland Press Ltd
Received:
July 15 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1339–1343.
Article history
Received:
July 15 2008
Citation
Martin W. Goldberg, Jindriska Fiserova, Irm Huttenlauch, Reimer Stick; A new model for nuclear lamina organization. Biochem Soc Trans 1 December 2008; 36 (6): 1339–1343. doi: https://doi.org/10.1042/BST0361339
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