Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative–antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation.
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December 2008
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Conference Article|
November 19 2008
Iron and calcium in the central nervous system: a close relationship in health and sickness
Ilaria Pelizzoni;
Ilaria Pelizzoni
*San Raffaele Scientific Institute, via Olgettina 60, I-20132 Milan, Italy
†Vita-Salute San Raffaele University, via Olgettina 60, I-20132 Milan, Italy
‡Italian Institute of Technology (IIT), Research Unit of Molecular Neuroscience, via Olgettina 60, I-20132 Milan, Italy
§Istituto Nazionale di Neuroscienze, via Olgettina 60, I-20132 Milan, Italy
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Romina Macco;
Romina Macco
*San Raffaele Scientific Institute, via Olgettina 60, I-20132 Milan, Italy
†Vita-Salute San Raffaele University, via Olgettina 60, I-20132 Milan, Italy
§Istituto Nazionale di Neuroscienze, via Olgettina 60, I-20132 Milan, Italy
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Daniele Zacchetti;
Daniele Zacchetti
*San Raffaele Scientific Institute, via Olgettina 60, I-20132 Milan, Italy
‡Italian Institute of Technology (IIT), Research Unit of Molecular Neuroscience, via Olgettina 60, I-20132 Milan, Italy
§Istituto Nazionale di Neuroscienze, via Olgettina 60, I-20132 Milan, Italy
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Fabio Grohovaz;
Fabio Grohovaz
1
*San Raffaele Scientific Institute, via Olgettina 60, I-20132 Milan, Italy
†Vita-Salute San Raffaele University, via Olgettina 60, I-20132 Milan, Italy
‡Italian Institute of Technology (IIT), Research Unit of Molecular Neuroscience, via Olgettina 60, I-20132 Milan, Italy
§Istituto Nazionale di Neuroscienze, via Olgettina 60, I-20132 Milan, Italy
1Correspondence may be addressed to either of these authors (email grohovaz.fabio@hsr.it or codazzi.franca@hsr.it).
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Franca Codazzi
Franca Codazzi
1
*San Raffaele Scientific Institute, via Olgettina 60, I-20132 Milan, Italy
‡Italian Institute of Technology (IIT), Research Unit of Molecular Neuroscience, via Olgettina 60, I-20132 Milan, Italy
§Istituto Nazionale di Neuroscienze, via Olgettina 60, I-20132 Milan, Italy
1Correspondence may be addressed to either of these authors (email grohovaz.fabio@hsr.it or codazzi.franca@hsr.it).
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Publisher: Portland Press Ltd
Received:
July 09 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Article history
Received:
July 09 2008
Citation
Ilaria Pelizzoni, Romina Macco, Daniele Zacchetti, Fabio Grohovaz, Franca Codazzi; Iron and calcium in the central nervous system: a close relationship in health and sickness. Biochem Soc Trans 1 December 2008; 36 (6): 1309–1312. doi: https://doi.org/10.1042/BST0361309
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