miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.
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December 2008
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Conference Article|
November 19 2008
Targeting of microRNAs for therapeutics
Jan Stenvang;
Jan Stenvang
*Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark
†Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark
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Morten Lindow;
Morten Lindow
*Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark
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Sakari Kauppinen
Sakari Kauppinen
1
*Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark
†Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark
1To whom correspondence should be addressed (email sk@santaris.com).
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Publisher: Portland Press Ltd
Received:
August 28 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1197–1200.
Article history
Received:
August 28 2008
Citation
Jan Stenvang, Morten Lindow, Sakari Kauppinen; Targeting of microRNAs for therapeutics. Biochem Soc Trans 1 December 2008; 36 (6): 1197–1200. doi: https://doi.org/10.1042/BST0361197
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