Post-transcriptional control of gene expression is an important mechanism for maintaining cellular homoeostasis and regulating the immune response to infection. It allows control of mRNA abundance, translation and localization. Mechanisms for post-transcriptional control involve RNA-binding proteins and miRNAs (microRNAs). The TTP(tristetraprolin) family of proteins recognize and bind AU-rich elements. Deletion of TTP led to a systemic autoimmune syndrome with excess circulating TNFα (tumour necrosis factor α) and GM-CSF (granulocyte/macrophage colony-stimulating factor) due to aberrantly stabilized mRNA. The family may also have a role in control of lymphocyte development and function. miRNAs regulate gene expression by promoting decay or inhibiting translation of transcripts with base pair complementarity. The importance of miRNAs in lymphocytes is highlighted by the T-cell-specific deletion of Dicer, an enzyme required for miRNA-mediated processing and from the phenotype of bic (B-cell integration cluster)/miR-155 (miRNA 155)-deficient mice.
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Conference Article|
November 19 2008
Regulation of B-cell differentiation by microRNAs and RNA-binding proteins
Alexander Ademokun;
Alexander Ademokun
1Laboratory of Lymphocyte Signalling and Development, the Babraham Institute, Cambridge CB22 3AT, U.K.
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Martin Turner
Martin Turner
1
1Laboratory of Lymphocyte Signalling and Development, the Babraham Institute, Cambridge CB22 3AT, U.K.
1To whom correspondence should be addressed (email martin.turner@bbsrc.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 19 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1191–1193.
Article history
Received:
August 19 2008
Citation
Alexander Ademokun, Martin Turner; Regulation of B-cell differentiation by microRNAs and RNA-binding proteins. Biochem Soc Trans 1 December 2008; 36 (6): 1191–1193. doi: https://doi.org/10.1042/BST0361191
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