Iron–sulfur (Fe–S) clusters are present in more than 200 different types of enzymes or proteins and constitute one of the most ancient, ubiquitous and structurally diverse classes of biological prosthetic groups. Hence the process of Fe–S cluster biosynthesis is essential to almost all forms of life and is remarkably conserved in prokaryotic and eukaryotic organisms. Three distinct types of Fe–S cluster assembly machinery have been established in bacteria, termed the NIF, ISC and SUF systems, and, in each case, the overall mechanism involves cysteine desulfurase-mediated assembly of transient clusters on scaffold proteins and subsequent transfer of pre-formed clusters to apo proteins. A molecular level understanding of the complex processes of Fe–S cluster assembly and transfer is now beginning to emerge from the combination of in vivo and in vitro approaches. The present review highlights recent developments in understanding the mechanism of Fe–S cluster assembly and transfer involving the ubiquitous U-type scaffold proteins and the potential roles of accessory proteins such as Nfu proteins and monothiol glutaredoxins in the assembly, storage or transfer of Fe–S clusters.
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Conference Article|
November 19 2008
Iron–sulfur cluster biosynthesis
Sibali Bandyopadhyay;
Sibali Bandyopadhyay
1Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602, U.S.A.
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Kala Chandramouli;
Kala Chandramouli
1Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602, U.S.A.
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Michael K. Johnson
Michael K. Johnson
1
1Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602, U.S.A.
1To whom correspondence should be addressed (email johnson@chem.uga.edu).
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Publisher: Portland Press Ltd
Received:
June 19 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1112–1119.
Article history
Received:
June 19 2008
Citation
Sibali Bandyopadhyay, Kala Chandramouli, Michael K. Johnson; Iron–sulfur cluster biosynthesis. Biochem Soc Trans 1 December 2008; 36 (6): 1112–1119. doi: https://doi.org/10.1042/BST0361112
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