Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour viral protein synthesis. Consequently, the study of viral translation has been a powerful tool for illuminating many aspects of cellular translational control. Although much work to date has focused on translational regulation by RNA viruses, DNA viruses have also evolved complex mechanisms to regulate protein synthesis. Here we summarize work on a large family of DNA viruses, the Herpesviridae, which have evolved mechanisms to sustain efficient cap-dependent translation and to regulate the translation of specific viral mRNAs.
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Conference Article| July 22 2008
Regulation of translation initiation by herpesviruses
Richard W.P. Smith;
Sheila V. Graham;
Nicola K. Gray
Nicola K. Gray 1
†MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, U.K.
‡Queens Medical Research Institute, School of Clinical Sciences & Community Health, Edinburgh University, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Richard W.P. Smith, Sheila V. Graham, Nicola K. Gray; Regulation of translation initiation by herpesviruses. Biochem Soc Trans 1 August 2008; 36 (4): 701–707. doi: https://doi.org/10.1042/BST0360701
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