The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.
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Conference Article| July 22 2008
Regulation of the RelA (p65) transactivation domain
John M. O'shea;
Neil D. Perkins
Neil D. Perkins 1
1College of Life Sciences, Wellcome Centre for Gene Regulation and Expression, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U.K.
1To whom correspondence should be addressed at the present address: Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Clifton, Bristol BS8 1TD, U.K. (email firstname.lastname@example.org).
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John M. O'shea, Neil D. Perkins; Regulation of the RelA (p65) transactivation domain. Biochem Soc Trans 1 August 2008; 36 (4): 603–608. doi: https://doi.org/10.1042/BST0360603
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