Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both the exosome and a 5′–3′-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains.
Control of mRNA degradation in trypanosomes
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Christine Clayton, Angela Schwede, Mhairi Stewart, Ana Robles, Corinna Benz, June Po, Martin Wurst, Rafael Quieroz, Stuart Archer; Control of mRNA degradation in trypanosomes. Biochem Soc Trans 1 June 2008; 36 (3): 520–521. doi: https://doi.org/10.1042/BST0360520
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