Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both the exosome and a 5′–3′-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains.
Control of mRNA degradation in trypanosomes
Christine Clayton, Angela Schwede, Mhairi Stewart, Ana Robles, Corinna Benz, June Po, Martin Wurst, Rafael Quieroz, Stuart Archer; Control of mRNA degradation in trypanosomes. Biochem Soc Trans 1 June 2008; 36 (3): 520–521. doi: https://doi.org/10.1042/BST0360520
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