Antioxidative defence mechanisms of pancreatic β-cells are particularly weak and can be overwhelmed by redox imbalance arising from overproduction of reactive oxygen and reactive nitrogen species. The consequences of this redox imbalance are lipid peroxidation, oxidation of proteins, DNA damage and interference of reactive species with signal transduction pathways, which contribute significantly to β-cell dysfunction and death in Type 1 and Type 2 diabetes mellitus. Reactive oxygen species, superoxide radicals (O2•−), hydrogen peroxide (H2O2) and, in a final iron-catalysed reaction step, the most reactive and toxic hydroxyl radicals (OH•) are produced during both pro-inflammatory cytokine-mediated β-cell attack in Type 1 diabetes and glucolipotoxicity-mediated β-cell dysfunction in Type 2 diabetes. In combination with NO•, which is toxic in itself, as well as through its reaction with the O2•− and subsequent formation of peroxynitrite, reactive species play a central role in β-cell death during the deterioration of glucose tolerance in the development of diabetes.
Skip Nav Destination
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article| May 21 2008
Oxidative stress: the vulnerable β-cell
Sigurd Lenzen 1
1Institute of Clinical Biochemistry, Hannover Medical School, 30625 Hannover, Germany
1Correspondence should be addressed at Institute of Clinical Biochemistry, Hannover Medical School, 30623 Hannover, Germany.
Search for other works by this author on:
Biochem Soc Trans (2008) 36 (3): 343–347.
November 13 2007
Sigurd Lenzen; Oxidative stress: the vulnerable β-cell. Biochem Soc Trans 1 June 2008; 36 (3): 343–347. doi: https://doi.org/10.1042/BST0360343
Download citation file:
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your InstitutionSign in via your Institution
Get Access To This Article
Buy This Article