Understanding pancreatic development is important for at least three reasons: first, from a cognitive point of view, to understand the development of a complex organ, the pancreas; next, because it is now clear that abnormal pancreatic development can give rise to specific forms of diabetes in humans; and finally, because, if we want to define new treatments for diabetes based on cell therapy or regenerative medicine, we will have to understand in detail how β-cells develop. In the present paper, we summarize what we currently know concerning pancreatic development and concentrate on some intercellular and environmental signals controlling pancreatic development.
Control of pancreatic development by intercellular signals
Bertrand Duvillié, Volodymyr Stetsyuk, Gaëlle Filhoulaud, Ghislaine Guillemain, Raphaël Scharfmann; Control of pancreatic development by intercellular signals. Biochem Soc Trans 1 June 2008; 36 (3): 276–279. doi: https://doi.org/10.1042/BST0360276
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