Sso0909 is a protein of the thermo-acidophilic crenarchaeon Sulfolobus solfataricus, annotated as a p60 katanin-like ATPase. We present here results supporting the hypothesis that Sso0909 is an orthologue of the eukaryotic ESCRT (endosomal sorting complex required for transport) ATPase Vps4 (vacular protein sorting 4). The spectrum of Sso0909 homologues is limited to several orders of Crenarchaea and to three euryarchaeal Thermoplasmata species, where they were presumably acquired by lateral gene transfer. Almost invariably, Sso0909 homologues occur in the genomic vicinity of homologues of eukaryotic ESCRT-III components, which are the targets of disassembly by Vps4, as well as with a creanarchaeal-specific coiled-coil protein. S. solfataricus sso0909 is constitutively expressed under normal growth conditions and appears to be essential, as judged by the failure to obtain stable deletion mutants. We expressed Sso0909 in Escherichia coli and S. solfataricus, but have not obtained preparations with ATPase activity so far.
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Conference Article|
January 22 2008
The Sulfolobus solfataricus AAA protein Sso0909, a homologue of the eukaryotic ESCRT Vps4 ATPase
Cédric F.V. Hobel;
Cédric F.V. Hobel
*Max-Planck Institute for Developmental Biology, Department of Protein Evolution, Spemannstrasse 35, 72076 Tübingen, Germany
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Sonja V. Albers;
Sonja V. Albers
†Department of Molecular Microbiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
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Arnold J.M. Driessen;
Arnold J.M. Driessen
†Department of Molecular Microbiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
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Andrei N. Lupas
Andrei N. Lupas
1
*Max-Planck Institute for Developmental Biology, Department of Protein Evolution, Spemannstrasse 35, 72076 Tübingen, Germany
1To whom correspondence should be addressed (email andrei.lupas@tuebingen.mpg.de).
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Publisher: Portland Press Ltd
Received:
October 30 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (1): 94–98.
Article history
Received:
October 30 2007
Citation
Cédric F.V. Hobel, Sonja V. Albers, Arnold J.M. Driessen, Andrei N. Lupas; The Sulfolobus solfataricus AAA protein Sso0909, a homologue of the eukaryotic ESCRT Vps4 ATPase. Biochem Soc Trans 1 February 2008; 36 (1): 94–98. doi: https://doi.org/10.1042/BST0360094
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