Simulations and modelling [e.g. with combined QM/MM (quantum mechanics/molecular mechanics) methods] are increasingly important in investigations of enzyme-catalysed reaction mechanisms. Calculations offer the potential of uniquely detailed, atomic-level insight into the fundamental processes of biological catalysis. Highly accurate methods promise quantitative comparison with experiments, and reliable predictions of mechanisms, revolutionizing enzymology.

Keywords:
biological catalyst, computational enzymology, enzyme-catalysed reaction mechanism, quantum mechanics/molecular mechanics (QM/MM), simulation, transition state
© The Authors Journal compilation © 2008 Biochemical Society
2008
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