Post-translational modification of proteins by SUMOs (small ubiquitin-related modifiers) plays an important role in a wide variety of biological processes. The mammalian SUMO family includes three members, SUMO-1, SUMO-2 and SUMO-3. While target proteins are predominantly conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro. In cells, SUMOs have the potential to multimerize via internal consensus sites for SUMOylation that are present in SUMO-2 and SUMO-3. A SUMO-binding motif in Ubc9 (ubiquitin-conjugating enzyme 9) contributes to SUMO chain formation in vitro and SUMO E3 ligases further enhance SUMO polymerization. SUMO chain formation is reversible; SUMO polymers are disassembled by SUMO proteases both in vitro and in vivo. Despite recent progress, the functional relevance of SUMO polymerization is still unclear and little is known about the identity of the endogenous target proteins that are conjugated to SUMO polymers.
Skip Nav Destination
Article navigation
December 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 23 2007
Small ubiquitin-related modifiers in chains
A.C.O. Vertegaal
A.C.O. Vertegaal
1
1Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
1email vertegaal@lumc.nl
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 22 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1422–1423.
Article history
Received:
June 22 2007
Citation
A.C.O. Vertegaal; Small ubiquitin-related modifiers in chains. Biochem Soc Trans 1 December 2007; 35 (6): 1422–1423. doi: https://doi.org/10.1042/BST0351422
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.