SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins.
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December 2007
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Conference Article|
November 23 2007
The role of Schizosaccharomyces pombe SUMO ligases in genome stability
F.Z. Watts;
F.Z. Watts
1
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
1To whom correspondence should be addressed (email f.z.watts@sussex.ac.uk).
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A. Skilton;
A. Skilton
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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J.C.-Y. Ho;
J.C.-Y. Ho
2
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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L.K. Boyd;
L.K. Boyd
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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M.A.M. Trickey;
M.A.M. Trickey
3
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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L. Gardner;
L. Gardner
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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F.-X. Ogi;
F.-X. Ogi
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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E.A. Outwin
E.A. Outwin
4
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
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Publisher: Portland Press Ltd
Received:
July 02 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1379–1384.
Article history
Received:
July 02 2007
Citation
F.Z. Watts, A. Skilton, J.C.-Y. Ho, L.K. Boyd, M.A.M. Trickey, L. Gardner, F.-X. Ogi, E.A. Outwin; The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Biochem Soc Trans 1 December 2007; 35 (6): 1379–1384. doi: https://doi.org/10.1042/BST0351379
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