Ligand-induced changes in cAMP concentration vary in duration, amplitude and extension into the cell. cAMP microdomains are shaped by adenylate cyclases that form cAMP as well as PDEs (phosphodiesterases) that degrade cAMP. Various extracellular signals converge on the cAMP/PKA (protein kinase A) pathway through ligand binding to GPCRs (G-protein-coupled receptors) and the cAMP/PKA pathway is therefore tightly regulated on several levels to maintain specificity in the multitude of signal inputs. AKAPs (A-kinase-anchoring proteins) target PKA to specific substrates and distinct subcellular compartments, providing spatial and temporal specificity for mediation of biological effects channelled through the cAMP/PKA pathway. AKAPs also serve as scaffolding proteins that assemble PKA together with signal terminators such as phosphoprotein phosphatases and cAMP-specific PDEs as well as components of other signalling pathways into multiprotein signalling complexes.
Skip Nav Destination
Article navigation
November 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2007
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
E. Jarnæss;
E. Jarnæss
1Biotechnology Centre of Oslo, University of Oslo, P.O. Box 1125, N-0317 Oslo, Norway
Search for other works by this author on:
K. Taskén
K. Taskén
1
1Biotechnology Centre of Oslo, University of Oslo, P.O. Box 1125, N-0317 Oslo, Norway
1To whom correspondence should be addressed (email kjetil.tasken@biotek.uio.no).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 10 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 931–937.
Article history
Received:
July 10 2007
Citation
E. Jarnæss, K. Taskén; Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem Soc Trans 1 November 2007; 35 (5): 931–937. doi: https://doi.org/10.1042/BST0350931
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.