Multiple sclerosis is an inflammatory, demyelinating and neurodegenerative disorder of the central nervous system. Increasing evidence indicates that neuronal pathology and axonal injury are early hallmarks of multiple sclerosis and are major contributors to progressive and permanent disability. Yet, the mechanisms underlying neuronal dysfunction and damage are not well defined. Elucidation of such mechanisms is of critical importance for the development of therapeutic strategies that will prevent neurodegeneration and confer neuroprotection. PMCA2 (plasma-membrane Ca2+-ATPase 2) and the NCX (Na+/Ca2+ exchanger) have been implicated in impairment of axonal and neuronal function in multiple sclerosis and its animal models. As PMCA2 and NCX play critical roles in calcium extrusion in cells, alterations in their expression or activity may affect calcium homoeostasis and thereby induce intracellular injury mechanisms. Interventions that restore normal PMCA2 and NCX activity may prevent or slow disease progression by averting neurodegeneration.
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November 2007
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Conference Article|
October 25 2007
Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers
M.P. Kurnellas;
M.P. Kurnellas
*Department of Neurology and Neuroscience, MSB, H-506, New Jersey Medical School, UMDNJ (University of Medicine and Dentistry of New Jersey), 185 South Orange Ave., Newark, NJ 07103, U.S.A.
†Neurology Service, Veterans Affairs, East Orange, NJ 07018, U.S.A.
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K.C. Donahue;
K.C. Donahue
*Department of Neurology and Neuroscience, MSB, H-506, New Jersey Medical School, UMDNJ (University of Medicine and Dentistry of New Jersey), 185 South Orange Ave., Newark, NJ 07103, U.S.A.
†Neurology Service, Veterans Affairs, East Orange, NJ 07018, U.S.A.
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S. Elkabes
S. Elkabes
1
*Department of Neurology and Neuroscience, MSB, H-506, New Jersey Medical School, UMDNJ (University of Medicine and Dentistry of New Jersey), 185 South Orange Ave., Newark, NJ 07103, U.S.A.
†Neurology Service, Veterans Affairs, East Orange, NJ 07018, U.S.A.
1To whom correspondence should be addressed (email elkabest@umdnj.edu).
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Publisher: Portland Press Ltd
Received:
June 15 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 923–926.
Article history
Received:
June 15 2007
Citation
M.P. Kurnellas, K.C. Donahue, S. Elkabes; Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers. Biochem Soc Trans 1 November 2007; 35 (5): 923–926. doi: https://doi.org/10.1042/BST0350923
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