Tumours are complex tissues composed of both matrix proteins and stromal cells such as fibroblasts and inflammatory cells. Tumour progression is often the result of dynamic interactions between the tumour cells and their surroundings. Lycopene, a natural carotenoid that is abundant in tomato, has been shown to inhibit proliferation of several types of cancer cells through arrest of tumour cell-cycle progression, IGF-1 (insulin-like growth factor 1) signalling transduction, induction of apoptosis etc. However, in our recent study, we found that lycopene inhibited PDGF-BB (platelet-derived growth factor-BB)-induced signalling and cell migration in human cultured skin fibroblasts through a novel mechanism of action, i.e. direct binding to PDGF-BB. Trapping of PDGF by lycopene also compromised melanoma-induced fibroblast migration and attenuated signalling transduction in fibroblasts simulated by melanoma-derived conditioned medium, suggesting that lycopene may interfere with tumour–stroma interactions. The trapping activity of lycopene on PDGF suggests that it may act as an inhibitor on stromal cells, tumour cells and their interactions, which may contribute to its anti-tumour activity.
Skip Nav Destination
Article navigation
November 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2007
Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer
W.-B. Wu;
W.-B. Wu
*School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan
Search for other works by this author on:
H.-S. Chiang;
H.-S. Chiang
*School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan
Search for other works by this author on:
J.-Y. Fang;
J.-Y. Fang
†Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan
Search for other works by this author on:
C.-F. Hung
C.-F. Hung
1
*School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan
1To whom correspondence should be addressed (email skin@mail.fju.edu.tw).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
May 22 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1377–1378.
Article history
Received:
May 22 2007
Citation
W.-B. Wu, H.-S. Chiang, J.-Y. Fang, C.-F. Hung; Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer. Biochem Soc Trans 1 November 2007; 35 (5): 1377–1378. doi: https://doi.org/10.1042/BST0351377
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.