Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle.
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Conference Article| October 25 2007
Mechanotransduction in striated muscle via focal adhesion kinase
M. Flück 1
*Institute of Anatomy, University of Berne, Berne, Switzerland
§Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke-on-Trent ST7 2HL, U.K.
1To whom correspondence should be addressed (email email@example.com).
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A.C. Durieux, D. Desplanches, D. Freyssenet, M. Flück; Mechanotransduction in striated muscle via focal adhesion kinase. Biochem Soc Trans 1 November 2007; 35 (5): 1312–1313. doi: https://doi.org/10.1042/BST0351312
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