The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.

Keywords:
cerebellar granule neuron, 5-hydroxyanthranilic acid, 3-hydroxykynurenine, kynurenine, quinolinic acid, tryptophan metabolite
© The Authors Journal compilation © 2007 Biochemical Society
2007
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